Asymmetric synthesis of 2-azido-1-arylethanols from azido aryl ketone-beta-cyclodextrin complexes and sodium borohydride in water

Citation
Ma. Reddy et al., Asymmetric synthesis of 2-azido-1-arylethanols from azido aryl ketone-beta-cyclodextrin complexes and sodium borohydride in water, CHEM COMMUN, (19), 2001, pp. 1974-1975
Citations number
24
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
19
Year of publication
2001
Pages
1974 - 1975
Database
ISI
SICI code
1359-7345(20011007):19<1974:ASO2FA>2.0.ZU;2-F
Abstract
beta -Cyclodextrin catalyses for the first time the asymmetric reduction of alpha -azido aryl ketones to corresponding alcohols of great significance using sodium borohydride in water. The azido group appeared to be the best fit among various groups studied. This asymmetric reduction using water as solvent overcomes many of the drawbacks in the existing methodologies.