Background and Purpose There is little information on the distribution
of atherosclerotic lesions of the extracranial carotid artery wall in
free-living populations. The purpose of the present study was to desc
ribe the prevalence from 1987 through 1989 of extracranial carotid art
ery plaque and plaque with acoustic attenuation (shadowing) lesions in
a general population of white and black adults from four US communiti
es. Methods B-mode ultrasound was used to characterize wall lesions in
the common and internal carotid arteries and at the carotid artery bi
furcation in 14 046 men and women 45 to 64 years old who participated
in the Atherosclerosis Risk in Communities Study baseline survey. Resu
lts Thirty-four percent of participants had plaque and 6.4% had plaque
with acoustic shadowing. The prevalence of plaque with acoustic shado
wing increased steadily with age from 2.5% at ages 45 to 49 to 12.4% a
t ages 60 to 64. Overall, whites had more plaque with acoustic shadowi
ng lesions than blacks (odds ratio [OR], 1.22; 95% confidence interval
[CI], 1.02 to 1.46), and men had more than women (OR, 1.42; 95% CI, 1
.22 to 1.63). However, plaque lesions in the common carotid artery wer
e less common among whites than among blacks, and no racial difference
was observed in the prevalence of plaque with acoustic shadowing at t
his segment. Conclusions Although these prevalence rates are likely to
be underestimated because of the emphasis on arterial boundary visual
ization of the scanning protocol, they show a large, mostly asymptomat
ic burden of atherosclerosis in these populations, especially among ol
der individuals. Site-specific frequency rates of plaque varied betwee
n blacks and whites. Among those with plaque, however, whites had more
lesions with acoustic shadowing attenuation.