Microwave induced synthesis of 3-aryl-6-( 6-/8-substituted 4-chloroquinoline-3-yl)-s-triazolo[3,4-b]-1,3,4-thiadiazoles

The condensation of 4-amino-3-aryl-5-mercapto-1, 2, 4-triazoles (1a-f) with 6-/8-substituted 1,4-dihydro-4-oxo-quinoline-3-carboxylic acids (2a-d) in the presence of phosphorus oxychloride on refluxing or under microwave irra diation gave twenty four novel 3-aryl-6- (6-/8-substituted 4-chloroquinolin e-3-yl)-s-triazlo[3,4-b]-1,3,4-thiadiazoles (4a-x), Considerable increase i n the reaction rate has been observed with improved yields under microwave irradiation. The structures of the compounds synthesized were determined by elemental analyses, IR, H-1 NMR and MS spectra. Their spectral properties and the reaction mechanism were also dis cussed. The preliminary biological test showed that some of compounds had moderate antibacterial activities.