Dynamics of postprandial remnant-like lipoprotein particles in serum afterloading of diacylglycerols

Background: To compare the effects of diacylglycerol (DAG) on postprandial lipid metabolism with triacylglycerol (TAG), we examined the differences in the dynamics of remnant lipoproteins after loading of DAG or TAG of the sa me fatty acid composition. Methods: The subjects were comprised of 6 male v olunteers who orally took creamed test meals prepared with either DAG or TA G at a dose of 30 g lipid/m(2) of body surface area in the early morning af ter fasting for at least 12 h. Blood was taken before and 2, 3, 4, 6 and 8 h after lipid loading, To quantify the amount of remnants, as the parameter s, we used concentrations of cholesterol (RLP-C) and triacylglycerol (RLP-T G) in remnant-like lipoprotein particles (RLP) of serum. Results: The serum triacylglycerol concentration was markedly increased 2 It after loading of DAG and TAG. Serum triacylglycerol concentrations at 2, 3 and 8 h after lo ading of DAG were significantly lower than those after loading of TAG. The serum RLP-C concentration was significantly lower 2, 3 and 8 h after loadin g of DAG than TAG. There was a trend toward less increase in the RLP-TAG in the DAG group. The area under the curve (AUC) of serum RLP-TAG after DAG l oading was significantly lower than that following TAG loading. Conclusions : DAG might reduce the risk of coronary arteriosclerotic diseases by weaken ing the postprandial increase of RLP that is known to be closely correlated with atherosclerosis. (C) 2001 Elsevier Science B.V, All rights reserved.