Neuro-ophthalmological manifestations of systemic lupus erythematosus in Asian patients

Purpose: To report eight patients with diagnosed systemic lupus erythematos us (SLE) who presented with a variety of neuro-ophthalmological complicatio ns and outcomes. Methods: A review of the follow up, subsequent management and outcomes of t he neuro-ophthalmological complications of eight patients with SLE. Results: The patients presented with a myriad of symptoms of varying severi ties. The most common manifestations were that of optic neuropathy and eye movement abnormalities. The outcome was variable ranging from complete reco very to optic atrophy with navigational visual acuity. Treatment was often empirical, although early treatment with corticosteroids has been tried wit h varying success. Conclusions: The pathophysiology in the neuro- ophthalmological manifestati ons of SLE is thought be due to vaso-occlusive disease of the small vessels of the nerve and brain, secondary to an autoimmune process. Ophthalmologis ts may need to consider the diagnosis of SLE in young women who present wit h a recent onset of neuro-ophthalmological symptoms and signs.