ENTEROBACTERIACEAE FROM COMMUNITY-ACQUIRE D URINARY-TRACT INFECTIONS - AFORCOPIBIO-1995

A prospective multicenter study was performed during two months (May a nd June 1995) by ten private clinical laboratories which collected 700 Enterobacteriaceae in 849 patients with community acquired urinary tr act infection. Isolated E. coli rate (70.2%) was the same as in 1990. Susceptibility to amoxicillin, amoxicillin-clavulanic acid, and cotrim oxazole had decreased. Susceptibility to fluoroquinolons, third genera tion cephalosporins, and fosfomycin remained stable. Among 178 E. coli cases, decreased susceptibility to aminopenicillin was mainly due to penicillinase (TEM-1: 86.5%; TEM-2: 1.7%, OXA: 1.7% and TRI: 5.7%) and in the other cases to the hyperproduction of cephalosporinase (2.8%), combined cephalosporinase + penicillinase (0.6%). P. mirabilis resist ant strains expressed penicillinase TEM-1 in five cases and TEM-2 in t hree cases. Among nn 53 other Enterobacteriaceae, 4 out of 18 K. Pnenm oniae produced an extended spectrum beta-lactamase (SHV-2 enzyme) and 7 out of 25 Enterobacteriaceae overproduced their chromosomal cephalos porinase.