The medial collateral ligament is one of the most frequently injured ligame
nts in the knee. Although the medial collateral ligament is known to provid
e a primary restraint to valgus and external rotations, details regarding i
ts precise mechanical function are unknown. In this study, strain in the me
dial collateral ligament of eight knees from male cadavers was measured dur
ing valgus loading. A material testing machine was used to apply 10 cycles
of varus and valgus rotation to limits of +/- 10.0 N-m at flexion angles of
0 degrees, 30 degrees, 60 degrees, and 90 degrees. A three-dimensional mot
ion analysis system measured local tissue strain on the medial collateral l
igament surface within 12 regions encompassing nearly the entire medial col
lateral ligament surface. Results indicated that strain is significantly di
fferent in different regions over the surface of the medial collateral liga
ment and that this distribution of strain changes with flexion angle and wi
th the application of a valgus torque. Strain in the posterior and central
portions of the medial collateral ligament generally decreased with increas
ing flexion angle, whereas strain in the anterior fibers remained relativel
y constant with changes in flexion angle. The highest strains in the medial
collateral ligament were found at full extension on the posterior side of
the medial collateral ligament near the femoral insertion. These data suppo
rt clinical findings that suggest the femoral insertion is the most common
location for medial collateral ligament injuries.