Patch test sensitization caused by para-tertiary-butylcatechol - Results of a prospective study with a dilution series

Citation
U. Hillen et al., Patch test sensitization caused by para-tertiary-butylcatechol - Results of a prospective study with a dilution series, CONTACT DER, 45(4), 2001, pp. 193-196
Citations number
9
Categorie Soggetti
Dermatology
Journal title
CONTACT DERMATITIS
ISSN journal
01051873 → ACNP
Volume
45
Issue
4
Year of publication
2001
Pages
193 - 196
Database
ISI
SICI code
0105-1873(200110)45:4<193:PTSCBP>2.0.ZU;2-P
Abstract
Para-tertiary-butylcatechol (PTBC) has been patch tested in Europe at 1% in petrolatum (pet.) and is now suspected of induction of patch test sensitiz ation. A prospective study was initiated to obtain detailed data on this un desirable risk. A dilution series of PTBC (1%, 0.5%, 0.25%, 0.1% pet.) was used. Patch tests were read on days (D) 1-3, 7, 14 and 21 after application . Patients who were unable to return for late readings were telephoned and asked to report any reaction at the patch test sites. 40 out of 46 patients included completed the study. Patch tests were negative in 35 patients. 4 patients showed a positive patch test at later readings only (D7-D21); 2 pa tients reacted to a concentration as low as 0.1%. Rechallenge was performed in 2 of these patients, revealing a clearly positive reaction as early as D2 after patch test application. PTBC clearly induced patch test sensitizat ion in 10% of the patients. It cannot be excluded that patch testing with 0 .25% PTBC or with even lower concentrations might induce patch test sensiti zation. The optimal patch test concentration still has to be determined but may be within the range of 0.01% to 0.25% PTBC. (C) Munksgaard, 2001.