U. Hillen et al., Patch test sensitization caused by para-tertiary-butylcatechol - Results of a prospective study with a dilution series, CONTACT DER, 45(4), 2001, pp. 193-196
Para-tertiary-butylcatechol (PTBC) has been patch tested in Europe at 1% in
petrolatum (pet.) and is now suspected of induction of patch test sensitiz
ation. A prospective study was initiated to obtain detailed data on this un
desirable risk. A dilution series of PTBC (1%, 0.5%, 0.25%, 0.1% pet.) was
used. Patch tests were read on days (D) 1-3, 7, 14 and 21 after application
. Patients who were unable to return for late readings were telephoned and
asked to report any reaction at the patch test sites. 40 out of 46 patients
included completed the study. Patch tests were negative in 35 patients. 4
patients showed a positive patch test at later readings only (D7-D21); 2 pa
tients reacted to a concentration as low as 0.1%. Rechallenge was performed
in 2 of these patients, revealing a clearly positive reaction as early as
D2 after patch test application. PTBC clearly induced patch test sensitizat
ion in 10% of the patients. It cannot be excluded that patch testing with 0
.25% PTBC or with even lower concentrations might induce patch test sensiti
zation. The optimal patch test concentration still has to be determined but
may be within the range of 0.01% to 0.25% PTBC. (C) Munksgaard, 2001.