The mechanism of action of DNA photolyases

Authors
Carell, T Burgdorf, LT Kundu, LM Cichon, M
Citation
T. Carell et al., The mechanism of action of DNA photolyases, CURR OP C B, 5(5), 2001, pp. 491-498
Citations number
43
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
5
Issue
5
Year of publication
2001
Pages
491 - 498
Database
ISI
SICI code
1367-5931(200110)5:5<491:TMOAOD>2.0.ZU;2-U
Abstract
Structural analysis, biochemistry and model studies have provided new insig hts into the mechanism of action of photolyases. The light-driven electron and energy transfer events that lead to the photolyase-catalyzed repair of lethal, mutagenic and carcinogenic UV-light-induced DNA lesions have all be en examined in the past few years.