Many different ligands of the TGF-beta superfamily signal in the early Xeno
pus embryo and are required for the specification and patterning of the thr
ee germ layers as well as for gastrulation. Recent advances in the field ar
e helping us understand how ligand activity is regulated both spatially and
temporally, the mechanism by which the signals are transduced to the nucle
us and how essentially the same signalling pathway can activate completely
different sets of genes in different regions of the embryo.