Neuropathic pain

Damage to peripheral nerves triggers a cascade of events in axotomized sens ory neurones that are generally believed to be responsible for the generati on of neuropathic pain. Recent data in animal models show that alterations in the properties of undamaged neurones that project into a damaged nerve c an also play an important role. These new findings could explain some of th e enigmatic clinical signs and symptoms of pain following nerve injury such as the spread of symptoms into areas not affected by the primary lesion. T he basis by which uninjured nerves could be affected is a reduced supply of neurotrophic factors, an abnormal interaction in the Remak bundles of part ially denervated Schwann cells and unmyelinated axons, or the byproducts of Wallerian degeneration. Curr Opin Neurol 14:641-647. (C) 2001 Lippincott W illiams & Wilkins.