Sweet's syndrome in association with Crohn's disease - Report of a case and review of the literature

A 41-year-old woman developed a skin rash as part of Sweet's syndrome concu rrent with the first episode of Crohn's disease of the colon. Sweet's syndr ome, acute febrile neutrophilic dermatosis, may be associated with inflamma tory, infectious, or neoplastic diseases. Its association with Crohn's dise ase is very rare, and when reported it has been mainly associated with Croh n's colitis. This association has been described in various stages of the d isease. Sweet's syndrome may be considered one of the extraintestinal manif estations of Crohn's disease. Early diagnosis of this dermatosis may be imp ortant because of the prompt response to treatment with corticosteroids. Th e value of metronidazole should be considered because this medication may e nhance response to treatment.