Chemical imaging sensor and its application to biological systems

The chemical imaging sensor is a semiconductor-based chemical sensor that c an visualize the two-dimensional distribution of chemical species in the sp ecimen. One of the prospective applications of the chemical imaging sensor is the visualization of biochemical activities in biological systems. The c hemical imaging sensor was successfully applied for the detection of Escher ichia coli colonies. For further applications to biological systems, enhanc ed adhesion of the sample to the sensing surface seems to be indispensable. As a candidate material for biocompatible sensors, porous Si was tested an d was found to have a high PH sensitivity of 57.3 mV/pH. (C) 2001 Elsevier Science Ltd. All rights reserved.