B. Shameena et al., Hypothyroidism and nutritional status alter 3,5,3 '-triiodothyronine (T-3)receptors in isolated liver nuclei of Anabas testudineus (Bloch), ENDOCRINE R, 27(3), 2001, pp. 329-336
T-3 receptors are ligand-dependent transcriptional activators that can stim
ulate gene expression resulting in growth and development. In this study T-
3 binding sites on isolated liver nuclei are demonstrated in the teleost An
abas testudineus. The effect of hypothyroidism and feeding of polyunsaturat
ed fatty acids (PUFA) on T-3 receptor number and binding affinity was also
studied. Hypothyroidism caused an increase in T-3 receptor number and a dec
rease in receptor affinity. PUFA feeding also increased the T-3 receptor nu
mber without any significant change in its receptor affinity.