A previously healthy woman developed hypersensitivity pneumonitis of such s
everity that she required chronic systemic corticosteroid therapy for sympt
om control. Detailed investigation of her workplace and home environments r
evealed fungi in her typical suburban home, to which she had specific serum
precipitating antibodies. Efforts to remove mold from the home were unsucc
essful in relieving symptoms, and moving to another residence was the only
intervention that allowed her to be withdrawn from corticosteroid therapy,
Hypersensitivity pneumonitis is commonly associated with occupational or av
ocational exposures, such as moldy hay in farmers or bird antigen in bird b
reeders. We propose that hypersensitivity pneumonitis may occur in North Am
erica, as it does in Japan, from domestic exposures alone.