Adrenomedullin and proadrenomudullin N-terminal 20 peptide (PAMP) are present in human colonic epithelia and exert an antimicrobial effect

Citation
M. Marutsuka et al., Adrenomedullin and proadrenomudullin N-terminal 20 peptide (PAMP) are present in human colonic epithelia and exert an antimicrobial effect, EXP PHYSIOL, 86(5), 2001, pp. 543-545
Citations number
12
Categorie Soggetti
Physiology
Journal title
EXPERIMENTAL PHYSIOLOGY
ISSN journal
09580670 → ACNP
Volume
86
Issue
5
Year of publication
2001
Pages
543 - 545
Database
ISI
SICI code
0958-0670(200109)86:5<543:AAPN2P>2.0.ZU;2-H
Abstract
The hypotensive and vasorelaxing peptides adrenomedullin (AM) and its gene- related peptide, proadrenomedullin N-terminal 20 peptide (PAW), were found to be distributed on the surface of the colonic mucosa. AM and PAMP showed dose-dependent antimicrobial activity against E coli. The results suggest t hat the novel vasoactive peptides AM and PAMP play an important role in muc osal defence.