Studies focusing on genetic and social influences on maternal adjustment wi
ll illumine mother's marriage, parenting, and the development of psychopath
ology in her children. Recent behavioral genetic research suggests mechanis
ms by which genetic and social influences determine psychological developme
nt and adjustment. First, heritable, personal attributes may influence indi
viduals' relationships with their family members. These genetically influen
ced family patterns may amplify the effects of adverse, heritable personal
attributes on adjustment. Second, influences unique to siblings may be the
most important environmental determinants of adjustment. We derive three hy
potheses on maternal adjustment from integrating these findings from geneti
c studies with other contemporary research on maternal adjustment. First, m
other's marriage mediates the influence of her heritable, personal attribut
es on her adjustment. Second, mother's recall of how she was parented is pa
rtially genetically influenced, and both her relationships with her spouse
and her child mediate the impact of these genetically influenced representa
tions on, her current adjustment. Third, characteristics of mother's spouse
are important influences on difference between her adjustment and that of
her sister's. These sibling-specific influences are unrelated to mother's h
eritable attributes. The current article develops this model, and the compa
nion article describes the Twin Mom Study that was designed to test it as w
ell, as its first findings. Data from this study can illumine the role of f
amily process in the expression of genetic influence and lead to specific f
amily interventions designed to offset adverse genetic influences.