A prospective study of stress among women undergoing in vitro fertilization or gamete intrafallopian transfer

Objective: To evaluate whether baseline or procedural stress during in vitr o fertilization (IVF) or gamete intrafallopian transfer (GIFT) affects preg nancy or live birth delivery rates. Design: Prospective study. Setting: Seven clinics in Southern California between 1993 and 1998. Patient(s): One hundred and fifty-one women completed two questionnaires. Intervention(s): None. Main Outcome Measure(s): The number of oocytes aspirated and fertilized, th e number of embryos transferred, the achievement of a pregnancy, live birth delivery, and infant outcomes. Result(s): Positive-affect negative-affect score at baseline negatively inf luenced the number of oocytes retrieved and embryos transferred. A higher e xpectation of pregnancy was associated with greater numbers of oocytes, fer tilized and embryos transferred. At baseline, the risk of no live birth was 93% lower for women who had the highest positive-affect score compared to those with the lowest score. Furthermore. the score on the Infertility Reac tion Scale was related to negative outcomes in Live birth delivery, infant birth weight, and multiple births. During the time of the procedure, the PA NAS and Bipolar Profile of Moods States results were related to the number of oocytes fertilized and embryos transferred; stress did not affect pregna ncy or delivery. Conclusion(s): Baseline (acute and chronic) stress affected biologic end po ints (i.e., number of oocytes retrieved and fertilized), as well as pregnan cy, live birth delivery, birth weight, and multiple gestations, whereas (pr ocedural) stress only influenced biologic end points. (Fertil Steril(R) 200 1;76:675-87. (C) 2001 by American Society for Reproductive Medicine.).