On the detection of linkage in multiple data sets: A comparison of variousstatistical approaches

Authors
Van Eerdewegh, P Dowd, M Dupuis, J Falls, K Hayward, B Santangelo, SL
Citation
P. Van Eerdewegh et al., On the detection of linkage in multiple data sets: A comparison of variousstatistical approaches, GENET EPID, 21, 2001, pp. S67-S72
Citations number
13
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENETIC EPIDEMIOLOGY
ISSN journal
07410395 → ACNP
Volume
21
Year of publication
2001
Supplement
1
Pages
S67 - S72
Database
ISI
SICI code
0741-0395(2001)21:<S67:OTDOLI>2.0.ZU;2-9
Abstract
We contrast the pooling of multiple data sets with the compound HLOD (HLOD- C) and the posterior probability of linkage (PPL), two approaches that have been shown to have more power in the presence of genetic heterogeneity. We also propose and evaluate several multipoint extensions. (C) 2001 Wiley-Li ss, Inc.