Family-based tests of association in the presence and absence of known linkage

Authors
Bertram, L Hayward, B Lake, SL Falls, K Van Eerdewegh, P Blacker, D
Citation
L. Bertram et al., Family-based tests of association in the presence and absence of known linkage, GENET EPID, 21, 2001, pp. S292-S297
Citations number
16
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENETIC EPIDEMIOLOGY
ISSN journal
07410395 → ACNP
Volume
21
Year of publication
2001
Supplement
1
Pages
S292 - S297
Database
ISI
SICI code
0741-0395(2001)21:<S292:FTOAIT>2.0.ZU;2-J
Abstract
Correlation among sibling marker genotypes may invalidate the results of fa mily-based tests of association in the presence of linkage. We apply an emp irical variance estimation method, which is implemented in the program pack age FBAT, on Caucasian families with asthma in the presence and absence of linkage and compare the results with those obtained using the TDT (TDTEX-PA IRS) on the same data sets. Our results indicate that both tests generally perform comparably in either setting. ((C))2001 Wiley-Liss, Inc.