Transmission/disequilibrium test analysis of total serum IgE levels in theHutterite and Collaborative Study on the Genetics of Asthma data sets

The Hutterite and Collaborative Study on the Genetics of Asthma data sets p rovided by Genetic Analysis Workshop 12 were analyzed using a regression-ba sed transmission/disequilibrium test that assesses linkage between a marker locus and quantitative trait locus when allelic association is present, as proposed by George et al. [Am J Hum Genet 65:236-45, 1999]. Because the sa me marker set and analytical technique was used, the results from these dat a sets are amenable for comparison. Statistically significant results commo n to both data sets were found on chromosomes 1 and 3. A noteworthy result, significant at p < 10(-4), was detected on chromosome 18 in the Hutterites . ((C))2001 Wiley-Liss, Inc.