Genome scan for linkage to asthma using a linkage disequilibrium-lod scoretest

We report a genome-wide linkage study of asthma on the German and Collabora tive Study on the Genetics of Asthma (CSGA) data. Using a combined linkage and linkage disequilibrium test and the nonparametric linkage score, we ide ntified 13 markers from the German data, I marker from the African American (CSGA) data, and 7 markers from the Caucasian (CSGA) data in which the p-v alues ranged between 0.0001 and 0.0100. From our analysis and taking into a ccount previous published linkage studies of asthma, we suggest that three regions in chromosome 5 (around D5S418, D5S644, and D5S422), one region in chromosome 6 (around three neighboring markers D6S1281, D6S291, and D6S1019 ), one region in chromosome 11 (around D1 1S2362), and two regions in chrom osome 12 (around D12S351 and D12S324) especially merit further investigatio n. ((C))2001 Wiley-Liss, Inc.