Evolution of the simulated data problem

The simulated data problem was designed via an interactive process by the S imulation Problem Organizing Committee and the selected data simulators. Ba sed on discussions at the previous Genetic Analysis Workshop, many of the f eatures of previous simulation problems, such as a complex disease, genome scan, and replication, were retained and in addition, a population genetics model was used to generate the simulated genes. We describe the process th at was used to structure the problem and summarize the discussions about ma ny of the scientific issues that were considered. (C) 2001 Wiley-Liss, Inc.