Parametric linkage analysis and disequilibrium methods to identify loci for complex disease

Citation
J. Mcclintick et al., Parametric linkage analysis and disequilibrium methods to identify loci for complex disease, GENET EPID, 21, 2001, pp. S528-S533
Citations number
10
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENETIC EPIDEMIOLOGY
ISSN journal
07410395 → ACNP
Volume
21
Year of publication
2001
Supplement
1
Pages
S528 - S533
Database
ISI
SICI code
0741-0395(2001)21:<S528:PLAADM>2.0.ZU;2-B
Abstract
A two-step process was used to find loci contributing to the qualitative di sease phenotype in the Genetic Analysis Workshop (GAW) 12 simulated data. T he first step used parametric linkage analysis with a limited number of dom inant and recessive models to detect linkage to chromosomal regions. Subseq uently, a subset of the simulated biallelic sequence polymorphisms was used for transmission/disequilibrium tests and to build haplotypes to fine map the disease-predisposing polymorphism(s). A haplotype, strongly associated with the disease phenotype whose proximal end was within 39 base pairs of t he functional allele for simulated major gene 6, was identified in the isol ated population. (C) 2001 Wiley-Liss, Inc.