Allelic association in large pedigrees

Authors
Gutin, A Abkevich, V Camp, NJ Farnham, JM Cannon-Albright, L Thomas, A
Citation
A. Gutin et al., Allelic association in large pedigrees, GENET EPID, 21, 2001, pp. S571-S575
Citations number
3
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENETIC EPIDEMIOLOGY
ISSN journal
07410395 → ACNP
Volume
21
Year of publication
2001
Supplement
1
Pages
S571 - S575
Database
ISI
SICI code
0741-0395(2001)21:<S571:AAILP>2.0.ZU;2-E
Abstract
We subjected the first replication of the simulated isolated population dat a set to a novel analysis for association between marker alleles and either disease phenotypes or quantitative variable. The analysis depends on being able to reliably reconstruct all haplotypes in the pedigree. This was achi eved using the MCLINK blocked Gibbs sampling program. We observed a highly significant association between the variable Q5 and marker D01G138, and sug gestive associations between the disease trait and markers D03G056 and D07G 004. (C) 2001 Wiley-Liss, Inc.