Does accounting for mitochondrial genetic variation improve the fit of genetic models?

Authors
Czerwinski, SA Williams, JT Demerath, EW Towne, B Siervogel, RM Blangero, J
Citation
Sa. Czerwinski et al., Does accounting for mitochondrial genetic variation improve the fit of genetic models?, GENET EPID, 21, 2001, pp. S779-S782
Citations number
15
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENETIC EPIDEMIOLOGY
ISSN journal
07410395 → ACNP
Volume
21
Year of publication
2001
Supplement
1
Pages
S779 - S782
Database
ISI
SICI code
0741-0395(2001)21:<S779:DAFMGV>2.0.ZU;2-4
Abstract
We describe a simple variance component model for estimating the effect of mitochondrial DNA (mtDNA) inheritance on quantitative trait variation. The model is applied to quantitative trait Q5 in the simulated general populati on data from Genetic Analysis Workshop (GAW) 12. Although the mitochondrial effect on Q5 is small (5,3%) and the power of the method to detect the eff ect is correspondingly low, analysis over the available population replicat es demonstrates that the effect of maternal relatedness can be detected and estimated accurately. (C) 2001 Wiley-Liss, Inc.