Role of wide/radical hysterectomy and pelvic lymph node dissection in endometrial cancer with cervical involvement

Objective. The goal of this work was to assess retrospectively the role of wide/radical hysterectomy (RH) and pelvic lymph node dissection (LND) in en dometrial cancer with cervical involvement. Methods. From 1984 to 1993, 82 patients with endometrial cancer and cervica l involvement were surgically managed at our institution. Of 57 patients wi th stage II (59%) or III (41%) disease receiving no preoperative therapy, 2 2 (39%) had simple hysterectomy (SH) and 35 (61%) had RE Forty-four patient s (77%) had pelvic LND, and 38 (67%) had adjuvant radiotherapy (RT). Median follow-up was 70 months. Results. The 5-year disease-related survival (DRS) and recurrence-free surv ival (RFS) were 73 and 63%, respectively. Five-year DRS and RFS were 68 and 50%, respectively, in the SH group compared with 76% (P=0.1) and 71% (P=0. 04) in the RH group. Distant recurrences occurred in 45% of patients with S H and in 23% with RH (P=0.08). Local recurrence rates did not differ signif icantly. Considering only stage II tumors, we did not observe any recurrenc e among patients with negative nodes who had RH, irrespective of the admini stration of adjuvant RT. By contrast, adjuvant RT improved local control (e ven if not significantly) in stage II patients who had SH. Five-year DRS of stage III patients was 47%, but it was improved by adjuvant RT in the subg roup of patients who had RH. Independent variables associated with prognosi s were stage III disease, deep myometrial invasion, RH, and adjuvant RT. Conclusion. RH and adjuvant RT appear to improve prognosis in endometrial c ancer with cervical involvement. In particular, radical surgery alone is th erapeutic in stage II patients with negative nodes, irrespective of the adm inistration of RT. By contrast, RT can possibly improve local control in st age II patients who previously had SH. Overall, stage III patients have a p oor prognosis that can be improved by a combination of radical surgery and adjuvant RT; however, associated therapy directed to extrapelvic sites is p robably needed in patients with extrauterine disease. (C) 2001 Academic Pre ss.