Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors

The aim of our study was to document whether relationships existed among bo ne morphogenetic proteins (BMPs), peripheral nerve and neoplastic lesions o f nerve sheath tumors. The mRNA transcriptions of BMP-2, 3, 4 and 5 in 10 c ases of schwannoma, three cases of malignant schwannoma and two cases of tr igeminal neuralgia were detected using an in situ hybridization technique. Our results demonstrated that the myelin sheaths of Schwann cell from the p eripheral neuroectomy of trigeminal neuralgia positively expressed mRNA of BMP-2, 3, 4, and 5. The most interesting finding was that the nerve fibers of trigeminal nerve showed only BMP-2 positive staining. All of the neoplas tic lesions of nerve sheath showed a consistent but variant expression of B MP-2, 3, 4, and 5. The expression signals of BMP-2, 3, 5 mRNA in malignant schwannoma were relatively lower than in benign lesions except for the expr ession of BMP-4 mRNA. Our results indicated that selected members of BMPs w ere expressed in the peripheral nerves that might contribute to the health maintenance, proliferation, regeneration and neoplastic transformation of t he peripheral nerve system. Furthermore, the effects of BMP-2, 3, 4 and 5 o n peripheral nervous system during neoplastic transformation might be wides pread, diverse and antagonistic.