Many simulation optimization approaches assume that a "good" starting point
is identified, that the design grid (i.e., spacing of runs for searching)
is known, and the only one basic search method need be employed. Often, how
ever, one or more of these items is unknown or is inappropriate. These assu
mptions can lead to an unnecessary expenditure of simulation runs, failure
to find the simulation optimum, and/or a false declaration of the optimal c
onditions. This article proposes that an approach based on best-first searc
h be used to determine the optimization starting region, starting point, an
d design grid. The best-first search works in concert with a divide-and-con
quer strategy for partitioning the search space and a safety net that acts
as a conservative check to prevent permanent pruning of desirable regions.
The methodology is demonstrated and shown to be successful on three example
problems.