BEDITINE, A NEW BENZODIOXANE DERIVATIVE, AS A SUPPRESSOR OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE AND PLATELET ACTIVATION

Authors
PANOSSIAN A GRIGORIAN G AKOPOV S AIVASIAN A MARKARIAN E VARTANIAN S GABRIELIAN E
Citation
A. Panossian et al., BEDITINE, A NEW BENZODIOXANE DERIVATIVE, AS A SUPPRESSOR OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE AND PLATELET ACTIVATION, Biochemical pharmacology, 53(11), 1997, pp. 1753-1755
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
Biochemical pharmacology → ACNP
ISSN journal
00062952
Volume
53
Issue
11
Year of publication
1997
Pages
1753 - 1755
Database
ISI
SICI code
0006-2952(1997)53:11<1753:BANBDA>2.0.ZU;2-O
Abstract
Beditine, 2-(2-amino-4-thiazolyl)-1,4-benzodioxane hydrochloride is a new substance which reduced platelet activation and degranulation, pre vented aggregation and superoxide generation by activated human polymo rphonuclear leukocytes (PMNL) and inhibited the activation of arachido nate 5-lipoxygenase. Beditine may, therefore, be a useful agent in the treatment of cardiovascular disease. (C) 1997 Elsevier Science Inc.