A. Panossian et al., BEDITINE, A NEW BENZODIOXANE DERIVATIVE, AS A SUPPRESSOR OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE AND PLATELET ACTIVATION, Biochemical pharmacology, 53(11), 1997, pp. 1753-1755
Beditine, 2-(2-amino-4-thiazolyl)-1,4-benzodioxane hydrochloride is a
new substance which reduced platelet activation and degranulation, pre
vented aggregation and superoxide generation by activated human polymo
rphonuclear leukocytes (PMNL) and inhibited the activation of arachido
nate 5-lipoxygenase. Beditine may, therefore, be a useful agent in the
treatment of cardiovascular disease. (C) 1997 Elsevier Science Inc.