Synthesis and biological activity of 6-fluoro-7-(substituted)-(2-n-p-anilino sulphonamido) benzothiazoles

Various substituted 6-fluoro-7- (substituted)- (2-N-p-anilino sulphonamido) benzothiazoles (VA(1)-(11)) containing different functional groups have be en synthesized by the condensation of 2-amino benzothiazole (II) with p-ace tamidobenzene sulphonyl chloride in pyridine and acetic anhydride mixture. The structure of the compounds V have been established on the basis of thei r chemical analysis and spectral data (IR, NMR & UV). All the compounds hav e been screened for their antibacterial, antifungal & inhibition of protein denaturation. Among the tested compounds 6-fluoro-7-(N-morpholino)(2-N-p-a nilino sulphonamido) benzothiazole (VA(8)) was found most potent.