Synthesis of new substituted-4 (3H)-quinazolinones and their antibacterialactivity

Authors
Patel, NB Lilakar, JD
Citation
Nb. Patel et Jd. Lilakar, Synthesis of new substituted-4 (3H)-quinazolinones and their antibacterialactivity, I J HET CHE, 11(1), 2001, pp. 85-86
Citations number
7
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
09711627 → ACNP
Volume
11
Issue
1
Year of publication
2001
Pages
85 - 86
Database
ISI
SICI code
0971-1627(200107/09)11:1<85:SONS(A>2.0.ZU;2-V
Abstract
Reaction of 2-[(2',6'-dichloro phenyl) amino] phenyl acetyl chloride (1) wi th anthranilic acid gave 2-[2'-(2 " ,6"-dichlorophenylamino)] phenyl methyl -3, 1-benzoxazine-4(H) one (II), which on further reaction with various sub stituted aryl amines yielded final compounds 2-[2'-(2",6"-dichlorophenylami no)] phenyl methyl-3-(substituted aryl)-4-(3H)-quinazolinones (IIIa-1). All the compounds were characterized by their spectral data, elemental analysi s and screened for antibacterial activity against gram positive and gram ne gative bacteria.