The PlA1/A2 polymorphism of platelet glycoprotein IIIa is not associated with deep venous thrombosis

Background. Platelet glycoprotein (GP) IIb/IIIa, a fibrinogen and von Wille brand factor binding membrane receptor, has an important role in platelet a ggregation. A common leucine33-proline polymorphism. (PlA1/A2) of the gene encoding the GP IIIa subunit is associated with platelet reactivity and has been proposed as a risk factor for atherothrombotic disease. The aim of th is study was to investigate the role of this polymorphism for deep venous t hrombosis (DVT). Methods. We performed a case-control study including 206 patients with docu mented DVT and a sex- and age-matched group of 310 control subjects. GP III a genotypes were determined by restriction fragment analysis of amplimers c ontaining the polymorphic site. Results. A1/A1, A1/A2 and A2/A2 genotypes were found in 67.0, 31.6 and 1.5% of patients and 72.3, 25.8 and 1.9% of controls (p=0.35), PlA2 allele freq uencies were 0.17 in patients and 0.15 in controls (p=0.92). Odds ratio of the PlA2 allele for DVT was 1.21 (95% CI 0.85-1.71, p=0.29) and remained in significant after adjustment for factor V Leiden and prothrombin 20210A gen otypes (1.22, 95% CI 0.86-1.75, p=0.27). Conclusions. Our data suggest that the PlA1/A2 polymorphism of GP IIIa is n ot associated with DVT.