Lack of association between polymorphisms of the coagulation factor VII and myocardial infarction in middle-aged Spanish men

In order to determine the role of two polymorphisms in the factor VII gene (R353Q and intron 7 hypervariable region) in the susceptibility to develop early myocardial infarction, a total of 175 patients with acute myocardial infarction aged 50 years or less (mean age 41 +/- 7 years) and 200 controls (average age 42 +/- 6) without cardiovascular disease were genotyped for t hese polymorphisms. Gene and genotype frequencies did not differ between pa tients and controls. Although the 353-QQ genotype was at a higher frequency among controls (4%) compared to patients (1%). the difference did not reac h statistical significance. Carriers of the H7-allele (intron 7 polymorphis m) were at a slightly higher frequency among patients (51 vs. 43%; P = 0.19 ; OR = 1.36; 95% CI = 1.09-1.70). Our data suggest a lack of association be tween both polymorphisms in the factor VII gene and early myocardial infarc tion in our population. (C) 2001 Elsevier Science Ireland Ltd. All rights r eserved.