Factors influencing drug release from stearic acid based compacts

Fatty acids are potentially suitable carriers for use in the design of drug delivery systems, being biocompatible. biodegradable inexpensive and of lo w toxicity. The release of the model compound benzoic acid from fatty acid compacts of stearic acid was evaluated using the USP Apparatus 2 dissolutio n assembly in phosphate buffer pH 7.4. Matrix controlled drug release was e xpected. Release profiles were approximated by square root of time kinetics . Release rate was independent of stirring speed in the rpm range 50-150, h owever, at 200 rpm a significant increase in release rate was observed part icularly at later times, the amount released versus square root of time plo ts becoming non-linear. Release was independent of compression pressure in the range 1-7 tons, The particle size of the benzoic acid and stearic acid used had a significant influence on release. The use of particles in the ra nge 250-500 mum gave release rate constants (k. g/cm(2) per min (0.5)) simi lar to 1.5 greater than those of smaller particle size (63-125 mum). The fo rmation factor (F) tended to increase exponentially with drug loading, the increase being steeper for compacts prepared from the larger particle sizes . At 80% drug loading for large sized systems the matrix appeared to offer little resistance to drug release and F approached one. (C) 2001 Elsevier S cience B.V. All rights reserved.