Evaluation of the mechanical destructive force in the stomach of dog

Orally administered dosage forms receive a destructive force in the gastroi ntestinal (GI) tract due to peristalsis. In this study. the destructive for ce was measured with a 'destructive force-dependent release system' (DDRS). DDRS is a press-coated tablet with an extremely brittle outer layer compos ed of highly hydrophobic Teflon((R)) powder, which is molded with a weak co mpression force. Teflon((R)) powder forms a porous but water-impermeable la yer around the core tablet, A marker drug contained in the core tablet is r eleased only when the tablet receives a force larger than its pre-determine d crushing strength. A comparison of the physiological conditions in the GI tract of dogs with those of humans. including the destructive force agains t tablets in the stomach, helps us to understand their difference in bioava ilability of oral dosage forms. With DDRS. it is possible to evaluate the d estructive force of both human and dog stomach using the same method. There fore, the destructive force data from human and dog can be directly compare d. The destructive force in the dog stomach was evaluated to be 3.2 N. whic h was considerably stronger than that or humans. (C) 2001 Published by Else vier Science B.V.