ENANTIOMERIC PURITY CONTROL OF CHIRALIC D RUGS

Citation
T. Beyrich et al., ENANTIOMERIC PURITY CONTROL OF CHIRALIC D RUGS, Die Pharmazie, 52(7), 1997, pp. 512-516
Citations number
35
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
00317144
Volume
52
Issue
7
Year of publication
1997
Pages
512 - 516
Database
ISI
SICI code
0031-7144(1997)52:7<512:EPCOCD>2.0.ZU;2-1
Abstract
The enantiomeric purity control of ephedrine-HCl, norephedrine-HCl, ma ndelic acid and levamisole-HCl is investigated by means of DSC and CD. The precision of thermal analysis increases with the difference of me lting points between enantiomer and eutectic. The interpretation of me lting enthalpy is more trustworthy than the onset temperature of melti ng. The thermogravimetric noticeable decomposition of levamisole prohi bits the DSC purity control, because the onset temperature of degradat ion is below he melting temperature, The CD of ephedrine and levamisto le is in the same size, therefore the purity of these compounds is det erminable with the same precision (s(rel) +/- 3%). The CD investigatio n in solution is preferable to the thermic solid matter analysis.