There has been a great change in manufacturing systems toward computer-cont
rolled flexible manufacturing systems (FMS). The design and operation of th
e FMS involve intricate and interconnected decisions that result in the max
imum performance of the system. However, the design and operational decisio
ns have been made separately in consideration of a single-system performanc
e measure. This paper presents a method for simultaneously determining desi
gn and control parameters of an FMS with the multiple performance objective
s via full-factorial design of experiments, regression analysis and comprom
ise programming. For a numerical example, the SIMAN simulator models a hypo
thetical FMS with six workstations. Eight design and control parameters are
simultaneously determined by compromising four performance measures that a
re formulated using regression analysis.