EFFECT OF TABLET DISINTEGRANTS ON THE DISSOLUTION STABILITY OF NALIDIXIC-ACID TABLETS

Widely divergent and progresssively decreasing dissolution rates were observed in three commercial brands of nalidixic acid tablets. The agi ng effect on the dissolution rate was unrelated to the disintegration times of the tablets. Inclusion of modified carboxy methyl cellulose ( Nymcel(R)) in fabricated tablets yielded superior dissolution performa nce which was unaffected even after storage at ambient temperature for four years. Thus the aging effect of nalidixic acid tablets could be overcome by the inclusion of super disintegrants like Nymcels in the t ablets.