The interaction between copper and coronary risk indicators

We studied the effects of external copper exposure on plasma copper, serum lipids, lipoproteins and apolipoproteins in workers who have excessive cont act with copper. Fifty-eight healthy Turkish males who were working in the copper processing industry and 33 control subjects were examined. Copper co ncentration was measured by flame atomic absorption spectrometry, lipid,and lipoprotein levels were detected by spectrophotometry and apolipoproteins were measured with a nephelometer. There was no significant difference in plasma copper between the workers an d the controls. However, in the worker group, the mean levels of TC, LDL-C, apoAI, apoB and Lp (a) were significantly higher while the mean level of H DL-C was significantly lower than that of the controls. In addition, there was a significant positive correlation between plasma copper and LDL-C only in the workers group. Our findings suggest that excessive contact with copper may contribute to c oronary risk factors.