Background: Headaches and sleep problems are common complaints in the
daily practice of the general practitioner. Since the relationship bet
ween headaches and sleep complaints is complex, clear models of intera
ction are needed for adequate diagnosis and treatment. Methods: All su
bjects, successively seen in a headache clinic during a defined period
, were subdivided based on the time of onset of cephalalgia. Subjects
who reported onset of headache on a long-term basis, during the noctur
nal or early morning (before final awakening) period, were systematica
lly studied by a headache clinic and a sleep disorders center. This su
bgroup represented 17% of the total headache group. Results: Although
the results of the headache clinic study did not differentiate this su
bgroup from the other patients, the sleep disorders center's interview
s and questionnaires demonstrated a significant impact of the sleep di
sorders on headache and daytime function. Nocturnal monitoring during
sleep identified specific sleep disorders in 55% of the subjects with
onset of headache during the nocturnal sleep period. Follow-up after t
reatment of the sleep disorder showed that all subjects with an identi
fiable sleep disorder reported either an improvement or absence of the
ir headache. The subjects identified with periodic limb movement syndr
ome were mostly those who reported only an improvement in their sleep
and still needed treatment for their headaches. The question of the in
teraction and association of sleep-related headache and periodic limb
movement syndrome is unresolved. Conclusion: Headaches occurring durin
g the night or early morning are often related to a sleep disturbance.