S. Zafar et al., Protective role of Delphinium denudatum (Jadwar) against morphine induced tolerance and dependence in mice, J ETHNOPHAR, 78(1), 2001, pp. 95-98
Chronic treatment with Delphinium denudatum (Dd) (Jadwar) (family: Ranuncul
aceae, 200-1600 mg/kg) suppressed morphine withdrawal jumps in a dose-depen
dent manner, a sign of the development of dependence to opiate as assessed
by naloxone (2 mg/kg) precipitation withdrawal on day 10 of testing in mice
. Repeated administration of Dd (200-1600 mg/kg) for 9 days attenuated the
development of tolerance to the analgesic effect of morphine (10 mg/kg), al
so produces significant change in tail-flick latency from the saline pretre
ated group in a dose-dependent manner. (C) 2001 Published by Elsevier Scien
ce Ireland Ltd.