Role of blood pressure in the progression of microalbuminuria in elderly Japanese type 2 diabetic patients: a 7-year follow-up study

This 7-year retrospective longitudinal study was carried out in order to cl arify the clinical features of elderly type 2 diabetic patients with microa lbuminuria. Elderly Japanese type 2 diabetic patients (n = 22; age 50 - 73 years) with microalbuminuria were studied retrospectively. Patients whose u rinary albumin excretion rate (UAER) decreased over 7 years were considered 'non-progressors' (n = 8) whereas those whose UAER increased were consider ed 'progressors' (n = 14). The mean 7-year level of glycosylated haemoglobi n (HbA(1c)) did not differ significantly between non-progressors and progre ssors but the mean 7-year blood pressure (BP) of progressors (101 +/- 8 mmH g) was significantly higher than that of nonprogressors (92 +/- 7 mmHg). In progressors who received no anti-hypertensive drugs, systolic BP was above the BP goal of 130/85 mmHg but mean BP and diastolic BP were below this go al. The results are consistent with the view that hypertension affects the progression of microalbuminuria; raised systolic BP may be a factor in this progression in elderly type 2 diabetic patients.