Expression of p73 in colorectal carcinoma: Clinicopathological relevance

p73 gene expression and its correlation with clinicopathological variables were examined in 92 patients (53 male, 39 female; age range 38 - 89 years) with colorectal carcinoma. Gene expression was determined by immunohistoche mical analysis of resected formalin-fixed and paraffin-embedded carcinoma s pecimens. When p73 staining of each specimen was divided into two modes (sm all expression, 0 - 50% and large expression, > 50%), small expression of p 73 was obtained in most cases. Tumour, grade, stage, site and size did not correlate with the mode of expression, but tumour recurrence differed accor ding to mode. Expression of p73 was also related to prognosis: large expres sion indicated a shorter survival period. Our findings suggest that p73 exp ression plays a role in inducing tumour recurrence, and that analysis of th e expression is useful in evaluating the clinical course of colorectal carc inoma post-surgery.