A multinational, multicentre, non-blinded, randomized study of moxifloxacin oral tablets compared with co-amoxiclav oral tablets in the treatment of acute exacerbation of chronic bronchitis

The aim of this study was to compare the efficacy and safety of once daily dosing with moxifloxacin (BAY 12-8039) with that of co-amoxiclav given thre e times daily for the treatment of acute exacerbation of chronic bronchitis (AECB). Moxifloxacin (one 400 mg tablet daily) was administered orally for 5 days and co-amoxiclav (three 625 mg tablets daily) was given orally for 7 days. The study was randomized, non-blinded, multinational (12 countries) and multicentre (68 centres). A total of 575 patients, all with clear sign s of AECB, were treated, 292 with moxifloxacin and 283 with co-amoxiclav. O f these, 512 patients were evaluable for efficacy (261 in the moxifloxacin group and 251 in the co-amoxiclav group). The primary efficacy parameter wa s clinical response at 14 days in the evaluable population. A clinical succ ess was classified as resolution or improvement of symptoms. Variables used to assess clinical response included wheeze, cough, dyspnoea, sputum volum e, rales and rhonchi. The success rate for moxifloxacin in the evaluable pa tients was 96.2% and that for co-amoxiclav was 91.6%. The 95% confidence in tervals for this difference (0.4%; 8.7%) indicate equivalence in the treatm ents. Sputum samples were taken from patients and 140 of these contained a pathogen, Haemophilus influenzae being the most frequently isolated, Moraxe lla catarrhalis and Streptococcus pneumoniae were also commonly isolated pa thogens. The eradication rate at 14 days in the evaluable patients was 87.7 % in the moxifloxacin group and 89.6% in the coamoxiclav group. Both drugs were well tolerated with no significant differences in the numbers of drug- related adverse events or the numbers of patients withdrawing because of an adverse event. These results and the broad spectrum of antibacterial activ ity make moxifloxacin a promising and safe alternative to conventional ther apy for the empirical treatment of AECB.