Neurological assessment of coma

The neurologist is often required to evaluate the unconscious patient from both the diagnostic and prognostic perspective. Knowledge of the anatomical basis of coma is essential for competent evaluation but must be combined w ith an understanding of the many, often multi-factorial, medical conditions that result in impaired consciousness. Consciousness is a state of awareness of self and the environment. This sta te is determined by two separate functions: awareness (content of consciousness) arousal (level of consciousness). These are dependant upon separate physiological and anatomical systems. Com a is caused by disordered arousal rather than impairment of the content of consciousness, this being the sum of cognitive and affective mental functio n, dependent on an intact cerebral cortex. The absence of all content of co nsciousness is the basis for the vegetative state. Arousal depends on an intact ascending reticular activating system and conn ections with diencephalic structures. Like awareness, arousal is not an all or nothing concept and gradations in awareness have been described in the past as inattentiveness, stupor, and obtundation. Such terms lack precision and coma can be more objectively assessed using measures such as the Glasg ow coma scale (GCS) (table 1). This analyses three markers of consciousness -eye opening, and motor and verbal responses-bringing a degree of accuracy to evaluation. The GCS arbitrarily defines coma as a failure to open eyes in response to v erbal command (E2), perform no better than weak flexion (M4), and utter onl y unrecognisable sounds in response to pain (V2). The GCS is of no diagnost ic value, but is a reliable way of objectively monitoring the clinical cour se of the patient with an acute cranial insult without elucidating cause.