Outcome of curative management of malignant tumours of the parotid gland

Purpose: The optimal management of malignant parotid gland tumours remains to be defined precisely. Specifically, a further understanding of the turno ut features that influence treatment outcome is needed. Materials and Methods: A retrospective review was conducted on 184 patients who were registered at the Princess Margaret Hospital with a diagnosis of a primary malignant parotid gland turnout. Results: All patients were initially managed with a parotidectomy, and post operative x-ray radiation therapy (XRT) was administered to 159 patients. T he actuarial 5-year cause-specific survival and locoregional control rates were 76% and 81%, respectively. The survival and locoregional control rates for patients treated with surgery alone versus surgery plus postoperative XRT were not statistically different. A multiple regression analysis identi fied only age and turnout category to be independently significant prognost ic factors for both survival and locoregional control. Conclusion: We would recommend that patients with malignant parotid gland t umours be managed with parotidectomy, followed by postoperative XRT for tum ours with residual disease, aggressive histology, and/or positive lymph nod es.