Penetration of radionuclides across the skin: Glucans as possible inhibitors of metals permeation

Authors
Kassai, Z Bauerova, K Koprda, V Sandula, J Harangozo, M
Citation
Z. Kassai et al., Penetration of radionuclides across the skin: Glucans as possible inhibitors of metals permeation, J RAD NUCL, 250(1), 2001, pp. 189-191
Citations number
8
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
ISSN journal
02365731 → ACNP
Volume
250
Issue
1
Year of publication
2001
Pages
189 - 191
Database
ISI
SICI code
0236-5731(200110)250:1<189:PORATS>2.0.ZU;2-M
Abstract
Penetration of Cs+, Cd2+ and Co2+ ions across an animal model of human skin (five-day-old rat skin) was studied in vitro in vertical diffusion cells. Glucans (fibrilary beta-glucan, carboxymethyl-chitosan-glucan) were used as permeation inhibitors with the aim to reduce the potential toxicological e ffect of these metals in humans. Of the glucans studied, carboxymethyl-chit osan-glucan was the more effective inhibitor. The dose-dependency of this e ffect was demonstrated.