EFFECT OF VISCUM-ALBUM IN THE INHIBITION OF LUNG METASTASIS IN MICE INDUCED BY B16F10 MELANOMA-CELLS

Effect of Iscador, an extract from semiparasitic plant Viscum Album on the inhibition of lung metastatic colony formation induced by B16F10 melanoma cells was studied in mice. Simultaneous administration of dru g (1.66 mg/dose) and B16F10 melanoma cells could inhibit lung nodule f ormation by 92%. Prophylactic drug administration produced and inhibit ion of 78.6% and drug administration five days after tumour induction produced 68.16% inhibition of lung nodule formation. Lung hydroxyproli ne and serum sialic acid levels were also lower in the tumour bearing animals treated with Viscum Album. The animals treated with simultaneo us drug administration had an increase of 71.34% in their life span.