S. Antony et al., EFFECT OF VISCUM-ALBUM IN THE INHIBITION OF LUNG METASTASIS IN MICE INDUCED BY B16F10 MELANOMA-CELLS, Journal of experimental & clinical cancer research, 16(2), 1997, pp. 159-162
Effect of Iscador, an extract from semiparasitic plant Viscum Album on
the inhibition of lung metastatic colony formation induced by B16F10
melanoma cells was studied in mice. Simultaneous administration of dru
g (1.66 mg/dose) and B16F10 melanoma cells could inhibit lung nodule f
ormation by 92%. Prophylactic drug administration produced and inhibit
ion of 78.6% and drug administration five days after tumour induction
produced 68.16% inhibition of lung nodule formation. Lung hydroxyproli
ne and serum sialic acid levels were also lower in the tumour bearing
animals treated with Viscum Album. The animals treated with simultaneo
us drug administration had an increase of 71.34% in their life span.