THE HETEROGENEOUS EXPRESSION OF CD80, CD86 AND OTHER ADHESION MOLECULES ON LEUKEMIA AND LYMPHOMA-CELLS AND THEIR INDUCTION BY INTERFERON

CD80 (B7/BB-1, B7-1) and CD86 (B70, B7-2) take an important role in th e interaction between T lymphocytes and antigen presenting cells (APCs ) as co-stimulatory molecules, We analyzed the manifestation of adhesi on molecules, including CD80 and CD86, on some leukemia and lymphoma c ells. Constitutive expression of CD80 and/or CD86 was frequently obser ved on B cell leukemia/lymphoma cells, while it is rare on myeloid leu kemia cells, Interferon-alpha (IFN-alpha) amplified the manifestation of MHC class I and interferon-gamma (IFN-gamma) did both class I and c lass II. We also showed CD80 could be induced by IFN-alpha on K562 cel ls, which were originally negative for CD80, Our data implies the immu notherapy via CD80 and CD86 for patients with hematological malignanci es and the possibility to enhance it using interferons.